Anatomy & Physiology: Current Research
Open Access

Polak S

Publications

• Review Article
  Merkel Cells and Merkel Cell Carcinoma of Genitourinary System Tumor with Aggressive Behavior and Poor Prognosis
  Author(s): Polakovicova S and Polak SPolakovicova S and Polak S
  
  Human Merkel cells (MCs) were first described by Friedrich S. Merkel in 1875 and named “Tastzellen” (touch cells). Merkel cells are primarily localized in the basal layer of the epidermis and concentrated in touch-sensitive areas. Their density varies among each anatomical site. Mostly they are concentrated in the palms of hands, predominantly in the finger pads, also in the soles and toes than in any other parts of the body. Concentration of MC in the external genitalia has not been studied, but some researchers detected some MCs in the male prepuce and in the female clitoris. Last year they were first described in the labia minora. Functionally they can be classified into some subpopulations with different functions: mechanoreceptive, endocrine, chemo sensitive. They belong to mechanoreceptors detecting tissue deformations and release various neurotransmitters to nerve e.. View More»
  DOI: 10.4172/2161-0940.1000289

  Abstract PDF

Relevant Topics