Journal of Cytology & Histology

Prasad R

Publications

• Research Article
  In vitro Anticancer Activities of Ethanolic Extracts of Dendrobium crepidatum and Dendrobium chrysanthum against T-cell lymphoma
  Author(s): Prasad R and Koch BPrasad R and Koch B
  
  Background: The orchid plants of Dendrobium, belong to the largest family of flowering plants orchidaceae. The genus Dendrobium reported to possess various therapeutic activities including anticancer activity. In the present scenario, cancer is one of the most leading causes of death worldwide. Therefore, the main objective of the present study was to demonstrate the cytotoxic and apoptotic inducing activity of Dendrobium crepidatum and Dendrobium chrysanthum ethanolic extracts in T-cell lymphoma. Methods: MTT assay was done to evaluate the cytotoxic effect of the extracts on lymphoma cells. The reactive oxygen species (ROS) generation by the ethanolic extracts was also examined by DCFH-DA. Fluorescence microscopy studies and DNA fragmentation assay were done to investigate the apoptotic cell death. Flow cytometry was done to check the effect of ethanolic extracts on cell cycle phase .. Read More»
  DOI: 10.4172/2157-7099.1000432

  Abstract PDF