Journal of Chemical Engineering & Process Technology
Open Access
ISSN: 2157-7048
+44-20-4587-4809
ISSN: 2157-7048
+44-20-4587-4809
Pritish Chowdhury
CSIR North East Institute of Science & Technology,
Jorhat 785 006
India
Research Article
A Simple Efficient Process for the Synthesis of 16-Dehydropregnenolone Acetate(16-Dpa) - A Key Steroid Drug Intermediate from Diosgenin
Author(s): Pritish Chowdhury, Juri Moni Borah, Manobjyoti Bordoloi, Pradip K. Goswami, Aradhana Goswami, Nabin C. Barua and Paruchuri G. RaoPritish Chowdhury, Juri Moni Borah, Manobjyoti Bordoloi, Pradip K. Goswami, Aradhana Goswami, Nabin C. Barua and Paruchuri G. Rao
A three step efficient synthesis for the commercial production of 16-dehydropregnenolone acetate (16-DPA)-a potent steroid drug intermediate, from diosgenin, in an overall yield of 60%, has been developed, through generation of acetylonium ion (CH3C+=O) in optimum concentration from acetic anhydride using in the molar ratio of 1:3.5(diosgenin:Ac2O) in a pressure reactor in a medium of a hydrocarbon solvent at a temperature in the range of 200oC with the corresponding in-built pressure of 5-6kg/cm2 (Step 1) and an ultra sound irradiated (35 KHz) oxidation reaction (Step 2)... View More»
DOI:
10.4172/2157-7048.1000117