Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Rawley C Howe
Ethiopia
Research Article
Immunological Profile: CD4, CD8, HIV Cofactors and Viral Load in HIV Discordant Couples when Compared with Concordant Couples
Author(s): Yohannis Meseret Hambissa, Dawit Wolday, Yohannes Mengistu, Aster Tsegaye, Rawley C Howe, Ermias Hailu, Nick Anderson, Geremew Tasew and Tsehaynesh MesseleYohannis Meseret Hambissa, Dawit Wolday, Yohannes Mengistu, Aster Tsegaye, Rawley C Howe, Ermias Hailu, Nick Anderson, Geremew Tasew and Tsehaynesh Messele
To assess if the differences between discordant couples were due to the differences of CD4, CD8; the absolute number and proportions of these T cells were determined using a flow cytometer and other HIV Co-factors and viral load was also measured and compared with concordant and AIDS patients. Discordant negative partners had adequate amount of CD4 equivalent to healthy subjects and highly significantly (P<0.001) different from discordant positives and CD4 and CD8 ratio was also high. Discordant positive partners had a significantly (P<0.05) different number of CD4 cells when compared to concordant couples. The CD4 number of discordant positive subjects was closer but slightly higher than the normal boundary count.
The CD8 number of discordant positives was very similar to discordant negatives and there was no significant difference (p>0.05). Increased CD8 number was a.. View More»
DOI:
10.4172/2155-9899.1000468