Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Robert J. Gillies
H. Lee Moffitt Cancer Center & Research Institute,
Tampa, FL 33612
Tanzania
Research Article
Buffer Therapy → Buffer Diet
Author(s): Christian Pilot, Amit Mahipal and Robert J. GilliesChristian Pilot, Amit Mahipal and Robert J. Gillies
Malignant tumors exhibit an increase in glucose metabolism when compared to normal tissue. The increased metabolism generates an acidic tumor environment, which promotes local invasion, metastasis, and inhibition of immune surveillance. Oral buffers, e.g. 200 mM ad lib NaHCO3, can neutralize tumor acidity and prevent metastasis and improve immune therapy. Because of these promising results in preclinical cancers, phase I/ II clinical trials were initiated in cancer patients for either amelioration of pain or treatment of pancreatic cancer (GemTABS). In these two trials, NaHCO3 was provided in powdered form under an IND. However, compliance remains poor due to adverse effects including, but not limited to, diarrhea, vomitus, limb edema, and taste. Because of these challenges with buffer therapy in the clinic, we have investigated whether dietary manipulations could achieve the same eff.. View More»
DOI:
10.4172/2155-9600.1000685