Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Rongbiao Ying
Taizhou Cancer Hospital,
Wenling, Zhejiang, 317500
China
Research Article
Integrin-Linked Kinase Inactives the Wnt Pathway through Connexin
Author(s): Youping Yang, Hongxia Lin, Yangli Zhu, Hongwei Wu, Ruoyan Wang, Jianmin Zhang, Linghui Zeng, Ximei Wu and Rongbiao YingYouping Yang, Hongxia Lin, Yangli Zhu, Hongwei Wu, Ruoyan Wang, Jianmin Zhang, Linghui Zeng, Ximei Wu and Rongbiao Ying
One of the hallmarks of cancers is the silencing of tumor suppressor genes and certain signaling pathways. The Wnt pathway is activated in many types of cancers, leading to tumor progression and metastasis. Here we demonstrated that integrin-linked kinase (ILK) plays a critical role in the suppression of the Wnt pathway via decreasing Wnt3a-induced stabilization of β-catenin, which leaded to the block of the functional gap-junctional intercellular communications (GJIC). Inhibition of ILK in prostate cells resulted in the inactivation of the Wnt pathway components GSK3β and inactivation of Lef1 transcription with concomitant inducing of connexins, which forming channels between adjacent cells. In line with the above changes, over-expression of connexin 43 (Cx43) also inhibited the activity of Lef1 transcription factor induced by Wnt3a media and th.. View More»
DOI:
10.4172/2167-0501.1000192