Ruchi Singh
Tanzania
Research Article
Correlation of Fibroblast Growth Factor 23 with Markers of Inflammation and Endothelial Dysfunction in End-Stage Renal Disease and Type 2 Diabetes Patients on Peritoneal Dialysis
Author(s): Ruchi Singh, Sudha P Chennasamudram, Sudip Sheth and Tetyana L VasylyevaRuchi Singh, Sudha P Chennasamudram, Sudip Sheth and Tetyana L Vasylyeva
Objective: This study was design to evaluate the correlation between FGF-23 and other cardiovascular risk factors (markers of endothelial dysfunction and inflammation) in ESRD patients with T2DM on PD.
Method: Sixty serum samples collected (four times, at weeks 0, 8, 10, and 18) from 15 patients with Type 2 Diabetes (T2DM) and ESRD on PD were analysed to study the relationship between the levels of FGF-23 and markers of endothelial dysfunction and inflammation. ELISA kits were used to quantitate Endothelin-1 (ET-1), soluble vascular adhesion molecule, Plasminogen Activator Inhibitor-1 (PAI-1), FGF-23, C-reactive protein, Interleukin-6 (IL-6), Tumor Necrosis Factor Alpha (TNF-α) and cluster of differentiation 146 (CD 146). The association between FGF-23, mineral metabolites, and markers of inflammation were analyzed using Spearman correlations. Linear regression models .. View More»
