Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Sara Baker Mostafa
Egypt
Research Article
Assessment of Urinary Interleukin-18 and Serum Amyloid A Efficacies against C-Reactive Protein in Diagnosis and Follow-up of Neonatal Sepsis
Author(s): Aliaa Monir Higazi, Doaa Mohamed Mahrous, Samira Zein Sayed, Osama Galal Mohamed, Sanaa Shaker Aly, Naglaa Makram Farag, Nashwa Nabil Kamal, Sara Baker Mostafa and Amira Mohsen MohammedAliaa Monir Higazi, Doaa Mohamed Mahrous, Samira Zein Sayed, Osama Galal Mohamed, Sanaa Shaker Aly, Naglaa Makram Farag, Nashwa Nabil Kamal, Sara Baker Mostafa and Amira Mohsen Mohammed
Objective: infection is a leading cause of morbidity and mortality in neonates. The aim of this study was to evaluate the diagnostic and prognostic performances of urinary interleukin-18 (uIL-18) and serum amyloid A (SAA) in neonatal sepsis parallel to C- reactive protein (CRP).
Subjects and methods: A total of 275 neonates were included in this case-control study. This study was conducted in neonatal intensive care unit at both Minia University Hospital for obstetric and pediatrics as well as Qena University hospital (Egypt). Among those 275 neonates, 150 non septic neonates - who had neither clinical signs nor laboratory findings suggestive of sepsis - were involved as a non-septic control group (Group II) and 125 septic neonates were classified as a septic group (group I). Blood and urine samples were obtained before initiation of antibiotic.. View More»
DOI:
10.4172/2155-9899.1000446