Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Sara Bottone
Italy
Research Article
A Crosstalk between Melatonin and Taste-Receptors’ Signaling Tunes Quinine-Induced Gut Hormone Secretion in Mice
Author(s): Gian Carlo Tenore, Sara Bottone, Gennaro Riccio, Nadia Badolati, Mariano Stornaiuolo and Ettore NovellinoGian Carlo Tenore, Sara Bottone, Gennaro Riccio, Nadia Badolati, Mariano Stornaiuolo and Ettore Novellino
Quinine consumption has been shown to reduce appetite and food intake in human and mice. Here, tested on two common mouse strains, C3H/lbg and C57BL/6J, it exerted a different effect. While quinine reduced weight gain in C3H/lbg mice, C57BL/6J were unaffected by the bitter molecule. Among the differences between the two strains, C57BL/6J present a blunted Melatonin production. In this study, we investigate if endogenous Melatonin is playing any role in the different response of C57BL/6J mice to quinine. The effect of dietary supplementation with Melatonin as well as of endogenous gastrointestinal and pineal produced Melatonin was investigated by supplementing quinine diet with pure Melatonin, L-Tryptophan or by reversion of light/dark cycle, respectively. The consumption of Melatonin reverts the phenotype and makes C57BL/6J mice sensitive to quinine. Similarly, quinine potency in C3H/.. View More»
DOI:
10.4172/2155-9600.1000664