Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Sergio Cerpa-Cruz
Hospital Civil de Guadalajara “Fray Antonio Alcalde”,
Guadalajara, Jalisco
Mexico
Review Article
Non-Alcoholic Fatty Steatohepatitis an Inflammatory Disorder Beyond the Liver
Author(s): Sergio Cerpa-Cruz, Verónica González-Díaz, Gloria Martínez-Bonilla, Sergio Gutiérrez-Ureña, Elsa Rodríguez-Cortés, Lizbeth A. Garcia-Espinosa, Miguel A Martínez-Valles and J Antonio Velarde-Ruiz-VelazcoSergio Cerpa-Cruz, Verónica González-Díaz, Gloria Martínez-Bonilla, Sergio Gutiérrez-Ureña, Elsa Rodríguez-Cortés, Lizbeth A. Garcia-Espinosa, Miguel A Martínez-Valles and J Antonio Velarde-Ruiz-Velazco
Non-alcoholic fatty liver disease (NAFLD) has emerged as the most prevalent chronic liver disease in the United States. Non-alcoholic steatohepatitis (NASH), the most severe form of NAFLD, has an increased risk for progression to cirrhosis and associated comorbidities such as cardiovascular disease. Metabolic syndrome (MS) including insulin resistance and obesity is central to the development of NASH. It is now estimated to affect 30% of adults and about 10% of children in the U.S. Hispanics are disproportionably affected with not only higher rates of NAFLD but also more severe disease. Emerging data indicate that NASH progression results from parallel events originating from the liver as well as from the adipose tissue, the gut and the gastrointestinal tract. Thus, dysfunction of the adipose tissue through enhanced flow of free fatty acids and release of adipocytokines, and alteratio.. View More»
DOI:
10.4172/2155-9899.1000159