Shakeela Zaman
Pakistan
Research Article
Association of Alpha-2 Beta-1 Integrin Polymorphism with Retinopathy in Diabetic Patients
Author(s): Nadeem Afzal, Nagi AH, Muhammad Imran, Abu Zafar, Amtul Musawar, Romeeza Tahir, Sarwar Abbas, Afia Abbas, Shakeela Zaman and Shah JahanNadeem Afzal, Nagi AH, Muhammad Imran, Abu Zafar, Amtul Musawar, Romeeza Tahir, Sarwar Abbas, Afia Abbas, Shakeela Zaman and Shah Jahan
Aim: Diabetes mellitus (DM) is a health concern because it leads to complications such as retinopathy and nephropathy. Pakistan has 6.9 million DM affected people that will be doubled by 2025. A study was designed to determine the role of genetics in diabetic retinopathy in Pakistani type 2 diabetes mellitus (T2DM) patients.
Material and methods: It was a cross-sectional case-control study that included 236 subjects, divided into Group I (54 volunteers without diabetes), Group II (30 T2DM patients without retinopathy) and Group III (152 T2DM patients with retinopathy). A BglII polymorphism of α2β1 integrin gene was genotyped in all these individuals by using RFLP method.
Results: The frequency of BglII polymorphism (++ and +-) genotypes was found significantly different between group I and group III individuals.
Conclusion: BglII (+/+, +/-) gen.. View More»
