Journal of Spine

Shan Quan Sun

Publications

• Case Report
  Protective Effect of Curcumin on Neural Myelin Sheaths by Attenuating Interactions between the Endoplasmic Reticulum and Mitochondria after Compressed Spinal Cord
  Author(s): Hai jun Yu, Lan Ma, Jin Jiang and Shan Quan SunHai jun Yu, Lan Ma, Jin Jiang and Shan Quan Sun
  
  Oligodendrocyte apoptosis is the leading cause of demyelination in the central nervous system after compressed spinal cord injury (CSCI). Curcumin, which belongs to the curcuminoid family, is a phenolic yellow pigment derived from the powdered rhizome of Curcuma longa. It has been proved that curcumin exhibits neuroprotective effects against traumatic spinal cord injury by inhibiting neuronal apoptosis. However, whether curcumin has a protective effect on demyelination after CSCI by inhibiting the apoptosis of oligodendrocytes has not been reported. Therefore this study was designed to investigate whether curcumin has a reparative effect on CSCI-induced demyelination and, if so, how it does so. First, we found that the administration of 100 mg/kg curcumin intraperitoneally (IP) 60 minutes after CSCI at days 1, 3, and 7 could significantly relieve neurological deficits. After staining .. Read More»
  DOI: 10.4172/2165-7939.1000322

  Abstract PDF