Medicinal & Aromatic Plants
Open Access
ISSN: 2167-0412
+44 1300 500008
ISSN: 2167-0412
+44 1300 500008
Shankar Jayarama
Teresian College,
Siddartha Nagar, Mysore, Karnataka
India
Research Article
Methanol Extract of Caesalpinia bonducella Induces Apoptosis via Up-
Regulation of Bax and Activation of PARP in Ehrlich Ascites Tumor Cells
Author(s): Priyanka Shivaprakash, Kaythegowdanadoddi Srinivasa Balaji, Gangadhar Maheskumar Lakshmi, Kagepura Thammaiah Chandrashekara and Shankar JayaramaPriyanka Shivaprakash, Kaythegowdanadoddi Srinivasa Balaji, Gangadhar Maheskumar Lakshmi, Kagepura Thammaiah Chandrashekara and Shankar Jayarama
Nature has endowed plants with the power to cure multitude of diseases. In case of cancer treatment, the search for natural agents with potential antitumor effect has been intensified with time. Here we are reporting analysis of methanol extract of Caesalpinia bonducella (MECB) for its anti-proliferative and pro-apoptotic effect on Ehrlich ascites tumor (EAT) model In-vivo. MECB at 200 mg/kg concentration was responsible for decrease in the total percent of viable EAT cells (51.6%) and ascites volume (65%) in treated mice. MECB increased the rate of apoptosis with more number of cells exhibiting characteristic features such as membrane blebbing, apoptotic body formation and fragmented DNA which was evident by Giemsa and Acridine orange/Ethidium bromide (AO/EB) staining. Alongside, the mice survival time was increased upon MECB treatment. In addition, FACS data sugges.. View More»
DOI:
10.4172/2167-0412.1000273