Journal of Blood & Lymph

Shimizu N

Publications

• Case Report
  Six Cases of Infectious Mononucleosis by Cytomegalovirus as Diagnosed by Multiplex Virus PCR Assay
  Author(s): Nagao M, Yoshioka Y, Saito T, Tsunemine H, Ito K, Kodaka T, Tsuji G, Watanabe K, Shimizu N and Takahashi TNagao M, Yoshioka Y, Saito T, Tsunemine H, Ito K, Kodaka T, Tsuji G, Watanabe K, Shimizu N and Takahashi T
  
  Infectious mononucleosis (IM) is mostly caused by Epstein-Barr virus (EBV) while IM by cytomegalovirus (CMV) is rather rare. In our retrospective clinical research with multiplex virus PCR analysis, we encountered 6 cases of CMV-IM and analyzed the clinical characteristics including diagnostic problems. The diagnosis of CMV-IM was made when the CMV genome was solely detected from the patient’s peripheral blood by multiplex virus PCR analysis. Then viral load was determined by quantitative PCR. Viral serological examinations were performed by a laboratory company as routine laboratory tests. Specific PCR signal for CMV genome was obtained by multiplex virus PCR in 6 patients, and blood CMV load ranged from 102 to 104 copies/mL. Clinical pictures and laboratory findings of these patients with CMV-IM were similar to those of EBV-IM in terms of fever, fatigue, morphology and number .. Read More»
  DOI: 10.4172/2165-7831.1000166

  Abstract PDF