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Shirai Y | OMICS International
ISSN: 2161-1149

Rheumatology: Current Research
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Shirai Y


IQGAP1 Mediates α-Smooth Muscle Actin Expression and Enhances Contractility of Lung Fibroblasts

Contractility is a predominant feature of myofibroblasts and a key process in fibrotic tissue remodeling. We previously demonstrated that lung fibroblasts from scleroderma patients with interstitial lung disease express a robust contractile phenotype and contain large amounts of the IQ motif containing GTPase activating protein (IQGAP1). Here we sh... Read More»

Akter T, Atanelishvili I, Shirai Y, Garcia-Martos A, Silver RM and Bogatkevich GS

: Rheumatology (Sunnyvale

DOI: 10.4172/2161-1149.1000242

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