Journal of Clinical & Medical Genomics

Si-Yi Chen

Publications

• Research Article
  Genetic Mutations in Human Esophageal and Gastric Cardia Cancers Detected by Ampliseq Sequencing
  Author(s): Jianguo Lu, Shangguo Liu, Bo Qi, Wenjian Yao, Xiuguang Qin, Ling Guo, Yu Cui, Chuanning Tang, Lindsey Jones, Hua Ye, Feng Lou, Dandan Zhang, Hong Sun, Yi Shi, Haichao Dong, Guangchun Zhang, Zhiyuan Liu, Zhishou Dong, Baishuai Guo, He Yan, Chaowei Yan, Lu Wang, Ziyi Su, Yangyang Li, Xue F Huang, Si-Yi Chen, Hanchen Li and Baosheng ZhaoJianguo Lu, Shangguo Liu, Bo Qi, Wenjian Yao, Xiuguang Qin, Ling Guo, Yu Cui, Chuanning Tang, Lindsey Jones, Hua Ye, Feng Lou, Dandan Zhang, Hong Sun, Yi Shi, Haichao Dong, Guangchun Zhang, Zhiyuan Liu, Zhishou Dong, Baishuai Guo, He Yan, Chaowei Yan, Lu Wang, Ziyi Su, Yangyang Li, Xue F Huang, Si-Yi Chen, Hanchen Li and Baosheng Zhao
  
  Esophageal and gastric cancers are two of the most common malignancies worldwide with particularly high mortality rates. Esophageal and gastric cardia cancers share certain environmental risk factors, but it is unclear if these cancers share similar gene mutation patterns. To improve patient diagnosis, treatment, and outcome, identification and characterization of the unique molecular mutation profiles of these cancers are needed to develop more effective target therapies. Until recently, personalized DNA sequencing to identify individual cancer mutations was unrealistic for clinical applications. But technological advancements in next-generation DNA sequencing, including the semiconductor-based Ion Torrent sequencing platform, have made DNA sequencing more cost and time effective with reliable results. Using the Ion Torrent Ampliseq Cancer Panel, we sequenced 737 loci from 45 cancer-.. Read More»
  DOI: 10.4172/2472-128X.1000119

  Abstract PDF