Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Sjosten ACE
Sweden
Research Article
Short-Term Impact of Starch Particles on Endometriotic Cells in vitro and in a Xenograft Nude Mouse Model
Author(s): Sjosten ACE, Gogusev J, Malm E, Sonden A, Ingelman-Sundberg H, Kjellstrom BT and Edelstam GABSjosten ACE, Gogusev J, Malm E, Sonden A, Ingelman-Sundberg H, Kjellstrom BT and Edelstam GAB
Purpose: Investigating the impact of starch powder on human endometriotic cells in vitro and on the implantation and development of adhesions in vivo. Basic procedure: In vitro - A human endometriotic cell line was incubated with different concentrations of starch particles and the effect on growth was measured by immunoassay. In vivo - Cells from a human endometriotic cell culture were injected with and without starch, into the peritoneal cavity of nude mice investigated 8, 15 respectively 22 days later. Main findings: In vitro - A low dose of starch particles significantly inhibited the proliferation of endometriotic cells during incubation for 48 h. In vivo - There were significant differences in the development of adhesions when the endometriotic cells were injected intraperitoneally together with starch particles. The.. View More»
DOI:
10.4172/2161-0932.1000154