Subhash C Juneja
Arthritis Program, Orthopedic Surgery, Toronto Western Hospital,
399 Bathurst St, Toronto, ON M5T 2S8
Canada
Research Article
A Less Invasive Approach of Medial Meniscectomy in Rat: A Model to Target Early or Less Severe Human Osteoarthritis
Author(s): Subhash C Juneja, Manuela Ventura, Gregory D Jay and Christian VeilletteSubhash C Juneja, Manuela Ventura, Gregory D Jay and Christian Veillette
Objectives: The existing medial meniscectomy (MMx) procedure in rodents involves transection of MCL and wide opening of the knee capsule followed by meniscus transection that results into articular cartilage degeneration and causes significant changes in subchondral bone at specific post-MMx period. These animals serve as experimental osteoarthritis (OA) models.
Structurally, knee is very complex. There may be a need to uncouple articular cartilage degenerative changes from subchondral bone degenerative changes in experimental OA models. Therapeutical drugs/agents, designed to treat articular cartilage degenerative changes of OA knee, may not be effective to treat subchondral bone degenerative changes or vice versa.
The purpose of the study was to modify the existing MMx procedure to a less invasive procedure so that it causes only articular cartil.. View More»
