Journal of Alcoholism & Drug Dependence
Open Access
ISSN: 2329-6488
ISSN: 2329-6488
Suril Gohel
Tanzania
Research Article
Modeling Causal Relationships among Brain Areas in the Mesocorticolimbic System during Resting-State in Cocaine Users Utilizing a Graph Theoretic Approach
Author(s): Suchismita Ray, Bharat B Biswal, Ashley Aya, Suril Gohel, Aradhana Srinagesh, Catherine Hanson and Stephen J. HansonSuchismita Ray, Bharat B Biswal, Ashley Aya, Suril Gohel, Aradhana Srinagesh, Catherine Hanson and Stephen J. Hanson
Objective: While effective connectivity (EC, causal interaction) between brain areas has been investigated in chronic users of cocaine as they view cocaine pictures cues, no study has examined EC while they take part in a resting-state scan. This resting-state fMRI study aims to investigate the causal interaction among brain areas in the mesocorticolimbic system (MCLS), which is involved in reward and motivation, in cocaine users (vs. controls).
Method: Twenty cocaine users and 17 healthy controls finished a structural and a resting-state scan. Mean voxel-based time series data were obtained from brain regions of interest (ROIs) from the MCLS, and were input into a Bayesian search algorithm called IMaGES.
Results: The causal interaction pattern was different between the two groups. The feed-forward pattern found in.. View More»
DOI:
10.4172/2329-6488.1000279