Journal of Glycobiology
Open Access
ISSN: 2168-958X
ISSN: 2168-958X
Susan M Smith
Australia
Research Article
The 7D4, 4C3 and 3B3 (-) Chondroitin Sulphation Motifs are expressed at Sites of Cartilage and Bone Morphogenesis during Foetal Human Knee Joint Development
Author(s): James Melrose, Susan M Smith, Clare E Hughes, Christopher B Little, Bruce Caterson and Anthony J HayesJames Melrose, Susan M Smith, Clare E Hughes, Christopher B Little, Bruce Caterson and Anthony J Hayes
Novel sulphation motifs within the glycosaminoglycan (GAG) chain structure of chondroitin sulphate (CS)- containing s are associated with sites of growth and differentiation in many biological systems where they function as molecular recognition sites involved in the binding, sequestration or presentation of soluble signalling molecules (e.g. growth factors, cytokines, morphogens). The specific sulphation motifs on CS identified by monoclonal antibodies 3-B-3(-), 4-C-3 and 7-D-4 are also associated with distinct cohorts of cells in areas of tissue morphogenesis in human foetal knee joint development. We hypothesize that such motifs may have roles to play in the regulation of proliferative/differentiative events during tissue morphogenesis. In the present investigation we have examined the distribution of these CS motifs within the rudiment cartilage, stromal connective tissues surroun.. View More»
DOI:
10.4172/2168-958X.1000118