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Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

+44 1223 790975

Suzanne T Ildstad

Suzanne T Ildstad
Institute for Cellular Therapeutics, University of Louisville CEO,
Regenerex, LLC 570 S. Preston Street, Suite 404 Louisville, KY 40202-1760
Tanzania

Publications
  • Review Article
    Facilitating Cells: A Journey from Bench to Bedside
    Author(s): Andrea R Merchak, Anita Chhabra and Suzanne T IldstadAndrea R Merchak, Anita Chhabra and Suzanne T Ildstad

    The development of safe conditioning protocols has reduced the morbidity and mortality of hematopoietic stem cell transplantation (HSCT), allowing broader application for treatment of a variety of non-malignant conditions including autoimmune diseases, hemoglobinopathies, metabolic disorders etc., as well as inducing tolerance to solid organ transplants. One of the most successful clinical trials using a facilitating cell enhanced HSCT paired with a kidney transplant has effectively induced tolerance in the absence of immunosuppressive drugs, maintaining the function of the transplanted kidney, and reconstituting the immunocompetence of the recipient. This novel protocol eliminates the need for immunosuppressive drugs, the key source of kidney and liver toxicity, increased malignancy, and shortened life span. CD8+ TCR facilitating cells (FC) are a population of tolerogenic cell which .. View More»
    DOI: 10.4172/2155-9899.1000545

    Abstract PDF

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