Journal of Vascular Medicine & Surgery

T Tran-Ngoc

Publications

• Research Article
  Comparison of Long Term Oxygen-Therapy (LTOT) and LTOT Combined with Sildenafil and Simvastatin in the Treatment of Severe Chronic Obstructive Pulmonary (COPD) with Hypoxia at Rest and Severe Pulmonary Arterial Hypertension
  Author(s): Huong Tran-Van, Anh Vo-Thi-Kim, T Tran-Ngoc and Sy Duong-QuyHuong Tran-Van, Anh Vo-Thi-Kim, T Tran-Ngoc and Sy Duong-Quy
  
  Background: Pulmonary arterial hypertension is frequent in patients with severe chronic obstructive pulmonary disease (COPD). It increases the morbidity and mortality of patients with advanced stage of COPD. The use of long-term oxygen therapy (LTOT) and some other vasodilators seems necessary to prevent pulmonary arterial hypertension (PAH) and right heart failure in these patients. Objective: This study was planned to compare the effect of LTOT alone and LTOT combined with sildenafil (PDE-5 inhibitor) and simvastatin (HMG CoA reductase inhibitor) on pulmonary arterial pressure of patients with severe COPD having hypoxia at rest. Methods: It was a cross-sectional and comparative study. All patients with severe COPD having hypoxia at rest (SpO2<88%) had been classified in three groups: Group 1 (treated with LTOT), Group 2 (treated with LTOT+sildenafil), and Group 3 (treated with LT.. View More»
  DOI: 10.4172/2329-6925.1000324

  Abstract PDF