Tadaatsu Imaizumi
Japan
Review Article
Mesangial Viral and Psuedoviral Immunity: Possible Involvement in the Pathogenesis of Pediatric-Onset Active Lupus Nephritis
Author(s): Hiroshi Tanaka and Tadaatsu ImaizumiHiroshi Tanaka and Tadaatsu Imaizumi
Background: Since viral infections activate type I interferon (IFN) pathways and cause subsequent release of IFN-dependent proinflammatory chemokines/cytokines, the innate immune system plays an important role in the pathogenesis of lupus nephritis (LN) as well as systemic lupus erythematosus. With respect to this issue, mesangial chemokine/cytokine expressions via innate immunity reportedly play a pivotal role in the pathogenesis of LN. Also, it has been reported that pediatric-onset active LN is found as having more severe acute inflammation than that of adult cases. Therefore, viral or “pseudoviral” infections may be attributable, at least in part, to the pathogenesis of LN, especially in pediatric-onset cases.
Methods: So far, we have examined the toll-like receptor (TLR) 3 signaling cascades treated with polyinosinicpolycyti.. View More»
