Molecular Biology: Open Access

Takashi Kondo

Publications

• Review Article
  DNA Damage Induced by Ultrasound and Cellular Responses
  Author(s): Yukihiro Furusawa and Takashi KondoYukihiro Furusawa and Takashi Kondo
  
  Ultrasonic technologies pervade the medical field as a long established imaging modality in clinical diagnostics and, with the emergence of targeted high-intensity focused ultrasound, as a means of thermally ablating tumors. Ultrasound (US) causes multiple thermal and non-thermal effects, such as mechanical and chemical stresses, that can result in damage to the cellular membrane and nucleus, leading to transient membrane pores, alterations in gene expression, and cell death, including apoptosis. On the basis of its biological effects US has been proposed as a new drug delivery and molecular targeting tool for cancer therapy. However, the molecular mechanisms involved in USinduced cell killing are not yet fully understood. Recently, we have reported that the mechanical effects of US elicit DNA single strand as well as double strand breaking- the most cytotoxic form of DNA damage, whic.. Read More»
  DOI: 10.4172/2168-9547.1000188

  Abstract PDF