Cardiovascular Pharmacology: Open Access

Takayama T

Publications

• Research Article
  NADPH Oxidase Inhibition in Heart Failure Improved Vascular Function Associated with Changes in the Novel Genes Expression Revealed by Transcriptome Analysis
  Author(s): Atsuyuki Wada, Matsumoto T, Takayama T, Taniguchi A, Masatake H, Fujii M, Tsutamoto T, Horie M and Isono TAtsuyuki Wada, Matsumoto T, Takayama T, Taniguchi A, Masatake H, Fujii M, Tsutamoto T, Horie M and Isono T
  
  Vascular endothelium-dependent vasorelaxation is diminished and reduced skeletal muscle blood flow and correlates with the severity of symptoms in heart failure (HF) as a result of the significant elevation of superoxide anion (O2-) production. There are several sources of (O2-) production within vessels, but NADPH oxidase is present in vascular smooth muscle cells and endothelial cells. Therefore oxidative stress may attenuate endothelial function and inhibition of this action may become one of the strategies to treat HF. We previously investigated the global transcriptome analysis in tachycardia-induced HF dogs and we selected four core genes, SOCS3, GADD45A, CDKN1A, and DUSP5 which were associated with the p53 pathway-related genes and the inflammatory interleukinrelated genes enhanced expression in HF. We examined therapeutic effects of apocynin (0.3 mg/kg/day) which suppressed ge.. View More»
  DOI: 10.4172/2329-6607.1000221

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