Immunome Research
Open Access
ISSN: 1745-7580
+44-20-4587-4809
ISSN: 1745-7580
+44-20-4587-4809
Takehiko Okamura
Anjo Kosei Hospital 28 Higashihirokute,
Anjo-cho, Anjo-shi, Aichi-ken 446-0026
Japan
Research Article
The Neutrophil-to-Lymphocyte Ratio as A Prognostic Factor For Long-Term Interleukin-2 Use in Renal Cell Carcinoma
Author(s): Takashi Nagai, Takehiko Okamura, Yutaro Tanaka, Daichi Kobayashi, Takahiro Kobayashi, Hidetoshi Akita and Takahiro YasuiTakashi Nagai, Takehiko Okamura, Yutaro Tanaka, Daichi Kobayashi, Takahiro Kobayashi, Hidetoshi Akita and Takahiro Yasui
The neutrophil-to-lymphocyte ratio (NLR), a measure of systemic inflammation, has been reported to be a predictive parameter of patient prognosis. We speculated that the NLR is decreased in renal cell carcinoma (RCC) patients in whom interleukin (IL)-2 is effective. In this study, we retrospectively examined the usefulness of the NLR as a prognostic factor using three cases of RCC treated with long-term IL-2. In all three cases, the NLR remained less than 2.7 during IL-2 treatment, suggesting its effectiveness as a marker. During interferon-α or molecular targeted drug therapy, the NLR was unstable, regardless of treatment effectiveness, but a sudden rise in the NLR tended to suggest massive radiographic progression and worse prognosis. The results suggested that the NLR might serve as a useful marker for therapies when determining prognosis.
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DOI:
10.4172/1745-7580.1000145