Tomoko Nakagami
abetes Center, Tokyo Women’s Medical University School of Medicine,
8-1, Shinjuku-ku, Tokyo 162-8666
Japan
Research Article
Assessment of Cholesterol Absorption and Synthesis in Japanese Patients with Type-2 Diabetes and Lipid-Lowering Effect of Ezetimibe
Author(s): Tomoko Nakagami, Yayoi Yamamoto, Sayaka Fukushima, Junko Oya, Yasuhiko Iwamoto and Yasuko UchigataTomoko Nakagami, Yayoi Yamamoto, Sayaka Fukushima, Junko Oya, Yasuhiko Iwamoto and Yasuko Uchigata
Aims: Cholesterol absorption is reported as an independent risk factor for cardiovascular disease. However, factors related to cholesterol absorption have not been fully examined in patients with type-2 diabetes (T2DM). The aim of this study was to assess cholesterol absorption/synthesis markers and the effect of an inhibitor of cholesterol absorption, ezetimibe, in patients with T2DM with hyper-low-density lipoprotein cholesterolemia. Methods: We included 59 patients treated with statins (S group) and 121 patients who were not receiving any Lipid lowering treatments (N group). Levels of cholesterol absorption and synthesis markers were compared between the 2 groups and between subjects in the N group with and without microvascular complications. The lipid-lowering effect of ezetimibe treatment (10 mg/day for 12 weeks) was examined in 70 patients with high levels of low-density lipo.. View More»
