Journal of Tissue Science and Engineering

TV Kumary

Publications

• Review Article
  Cell Sheet Technology using Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Tissue Engineering
  Author(s): Lakshmi R Nair and TV KumaryLakshmi R Nair and TV Kumary
  
  With limited regenerative capacity and most complex structural and electrophysiological properties; recapitulating the cardiac tissue is a challenging task for the researchers. The cell injection was found unreliable due to the cell loss and low retention of the transplanted cells. This could be overcome by the technique of cell sheet engineering. Scaffold free, thick, cell dense, three dimensional constructs could be generated for suture free transplantation. For the generation of the cardiac constructs the neonatal cardiomyocytes and myoblasts were mostly used. They were tedious to isolate and culture and the risk of arrhythmogenic foci prevailed. Hence the concept of differentiating a suitable allogeneic cell source to myocardial lineage seemed relevant. Human umbilical cord mesenchymal stem cells (hUCMSCs) are emerging with the assistance of differentiating agents and cell sheet e.. Read More»
  DOI: 10.4172/2157-7552.1000178

  Abstract PDF