Ujendra Kumar
Canada
Research Article
Up-Regulation of Iba-1 and GFAP in the Acidic Saline Model of Chronic Widespread Musculoskeletal Pain: A Pilot Study Examining the Relationship Between Gliosis and Hyperalgesia
Author(s): Dana M Lambert, Ujendra Kumar and Hafeli ODana M Lambert, Ujendra Kumar and Hafeli O
Chronic widespread musculoskeletal pain is a major cause of disability. Pro-inflammatory glial cell activity, also known as gliosis, has been associated with the development and maintenance of hyperalgesia within several forms of chronic pain, yet its role in the pathophysiology of chronic widespread musculoskeletal pain has not been clearly established. The aim of this study was to quantitatively compare the expression of glial cells in the acidic saline (AS) model of chronic widespread musculoskeletal pain with controls and determine whether a relationship exists between glial cell expression and pain response. Activation markers of astrocytes (GFAP) and microglia (Iba-1), detected via immunohistochemistry, were quantitatively analyzed in the lumbar spinal cord and thalamus ventrobasal complex. Hyperalgesia was determined using electronic algesiometer measurement of cutaneous mechan.. View More»
