Journal of Drug Metabolism & Toxicology
Open Access
ISSN: 2157-7609
+44-20-4587-4809
ISSN: 2157-7609
+44-20-4587-4809
Varsha Singh
School of Medical and Allied Sciences,
Plot No-17-A, Greater Noida, Uttar Pradesh
India
Review Article
Metabolism of Drugs with Inhibition of Enzymes
Author(s): Varsha Singh, Pramod Kumar Sharma and Md Aftab AlamVarsha Singh, Pramod Kumar Sharma and Md Aftab Alam
Drug metabolism is a process which is very important for the living organisms and thus provides various metabolic sites at various levels. The major site for the metabolism of drug is liver, whereas the first pass metabolism occurs. Enzymes usually catalyse every biochemical process inside the body. This review focuses on the metabolism of drugs with the need of inhibition of enzymes showing new developments in the art of enzyme inhibition. It shows methods for the inhibition of enzymes with the use of enzyme inhibitors as therapeutic agents and antimicrobial agents. It also shows the various effects like of ethanol, tobacco and diet on the metabolism of drug. It also describes the aapplication of competitive inhibitors in Pharmaceutical medicine with the help of COX-1 and COX-2 enzyme inhibitor. The differences in between COX-1 and COX-2 inhibitors have also been described in this revie.. View More»
DOI:
10.4172/2157-7609.1000233