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Research Article
Innate Immune Responses in the Neutrophils of Community Dwelling and Nursing Home Elders
Author(s): Manisha Juthani-Mehta, Xiuyang Guo, Albert C. Shaw, Virginia Towle, Yuming Ning, Xiaomei Wang, Heather G. Allore, Erol Fikrig and Ruth R. MontgomeryManisha Juthani-Mehta, Xiuyang Guo, Albert C. Shaw, Virginia Towle, Yuming Ning, Xiaomei Wang, Heather G. Allore, Erol Fikrig and Ruth R. Montgomery
Objective: To evaluate innate immune responses of older disabled nursing home residents that may contribute to infectious disease susceptibility, we compared surface markers and signaling efficiency of neutrophils from nursing home residents and community dwelling elders. Design: Observational pilot study. Setting: Five New Haven, CT area nursing homes and the greater New Haven community. Participants: 15 nursing home residents and 43 community dwelling elders. Measurements: Neutrophils were isolated and Toll-like receptor (TLR) and β2 integrin expression on the surface of unstimulated neutrophils were measured via flow cytometry. Chemokine induction was determined by Quantitative PCR. Results: Surface expression of TLR4 was elevated among nursi.. View More»
DOI: 10.4172/2329-8847.1000115