Walid Shehab-Eldin
Egypt
Research Article
The Effect of Hepatitis C Virus Eradication with New Direct Acting Antivirals on Glucose Homeostasis in Non-Diabetic Egyptian Patients
Author(s): Walid Shehab-Eldin, Ali Nada, Azza Abdulla and Somaia Shehab EldeenWalid Shehab-Eldin, Ali Nada, Azza Abdulla and Somaia Shehab Eldeen
Introduction: Chronic hepatitis C (HCV) infection and Diabetes Mellitus (DM) are common health problems in Egypt. HCV treatment by the new Direct Acting Antiviral (DAA) drugs gives hope to eradicate HCV. However, its effect on glucose homeostasis is not studied.
Aim: Study of glucose homeostasis before and after treatment of HCV infected patients with DAA drugs.
Subjects and methods: Eighty patients chronically infected with HCV, diagnosed by quantitative PCR, were subjected to physical examination and anthropometric measurements. In addition, FBS, fasting insulin, CBC, bilirubin, AST, ALT, Serum Albumin and serum creatinine were assessed at the beginning of the study. HOMA-IR, β cell %, BMI and e GFR were calculated. All patients received DAA drugs ± ribavirin for 3 months. All parameters were reassess.. View More»
