Journal of Clinical & Experimental Dermatology Research
Open Access
ISSN: 2155-9554
ISSN: 2155-9554
Xiaojun Wang
Department of Plastic Surgery of Peking Union Medical College Hospital,
Beijing
China
Research Article
Resveratrol Inhibits Proliferation and Promotes Apoptosis of Keloid Fibroblasts by Targeting HIF-1α
Author(s): Loubin Si, Qin Han, Xiao Long, Fei Long, Robert Chunhua Zhao, Jiuzhuo Huang, Zhifei Liu, Ru Zhao, Hailin Zhang and Xiaojun WangLoubin Si, Qin Han, Xiao Long, Fei Long, Robert Chunhua Zhao, Jiuzhuo Huang, Zhifei Liu, Ru Zhao, Hailin Zhang and Xiaojun Wang
Keloid is characterized by red, tickling, hard and irregular raised tissues, and tends to outgrow its origin. It occurs frequently in young adults and appears as refractory to prevailing therapies. Although histological studies have revealed striking similarities of keloids with cancer, such as uncontrolled cell growth, and many of the therapies in clinical practice including -fluorouracil and tamoxifen, excision, and radiation therapy were borrowed from cancer management, the etiology of keloid has remained to be explored to provide insights for developing effective therapeutic modalities. Hypoxic stress around tumors was frequently reported as conferring growth momentum to tumor cells. The hypoxia caused by fast growing of keloid fibroblasts may also be a risk factor that antagonizes therapies. Resveratrol has received intense attention in cancer researches since its anti-proliferat.. View More»
DOI:
10.4172/2155-9554.1000436