Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Xiaozhu Liu
Guizhou Institute of Technology,
Guiyang, 550000, Guizhou
China
Research Article
The Effect of High-Dose Simvastatin Therapy on Patients with Acute Cerebral Infarction
Author(s): Xiaozhu Liu, Huankun Liang, Kangyan Li, Jiali Li, Laiqing Li and Licheng ZhangXiaozhu Liu, Huankun Liang, Kangyan Li, Jiali Li, Laiqing Li and Licheng Zhang
Cerebrovascular disease (CVD) accounts for the major cause of morbidity and mortality in industrialized countries. However, effects of high-dose simvastatin therapy on patients with acute cerebral infarction still unclear. In this study, the clinical efficacy of high-dose simvastatin on patients with cerebral infarction was investigated. A total of 180 patients with acute cerebral infarction were randomized divided into control group (n=60), high-dose simvastatin (HDS) group (n=60) and low-dose simvastatin (LDS) group (n=60). Control group, HDS group and LDS group received conventional treatment, conventional treatment together with simvastatin 80 mg/d and conventional treatment as well as simvastatin 40 mg/d respectively for 3 months. Biochemical indices, neurological deficit and plaque thickness and volume were assessed and recorded after treatment. After simvastatin treatment, the .. View More»
DOI:
10.4172/2155-9880.1000527