Hereditary Genetics: Current Research

Yang Zhang

Publications

• Research Article
  Association between Decreased Plasma Folate Levels and MTHFR C677T, and MTRR A66G Gene Polymorphisms as Determinants for Elevated Total Homocysteine Concentrations in Pregnant Women
  Author(s): Cang-Sang Song, Wen-Bin Song, Jin-Ying Bao, Jing Luo, Xin Zuo, Ni An and Yang ZhangCang-Sang Song, Wen-Bin Song, Jin-Ying Bao, Jing Luo, Xin Zuo, Ni An and Yang Zhang
  
  Aims: The aims of this paper were to examine the association between gene polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G with levels of plasma folate and tHcy. Methods: Peripheral venous blood samples were obtained from 143 pregnant women, who had been fasted for more than 10 hours. Plasma tHcy and folate concentrations were measured in plasma specimens. The genotypes for polymorphisms were identified by the PCR-restriction fragment length polymorphism (RFLP). Results: Our results demonstrated that MTHFR 677T allele was the predictors of plasma folate levels in pregnant women. While MTHFR 677TT genotype and MTRR 66G allele were the predictors of plasma tHcy concentrations. Plasma folate levels were negatively correlated with tHcy concentrations (Pearson&rs.. View More»
  DOI: 10.4172/2161-1041.1000193

  Abstract PDF