Yapin Gan
IR Iran
Research Article
Astragaloside IV and Statin Increased the Islet Function and Proliferation for Beta Cells in STZ-Induced Diabetic Mice
Author(s): Mincai Li, Tonghui She, Yapin Gan, Juan Shao, Suqin Li, Wenli Liao, Hongli Xia, Liangzu Yu and Zhengwu HuMincai Li, Tonghui She, Yapin Gan, Juan Shao, Suqin Li, Wenli Liao, Hongli Xia, Liangzu Yu and Zhengwu Hu
Objective: Diabetic
hyperglycemia
causes a variety of pathological process involved in metabolic changes. Astragaloside IV (AS-IV) was widely used for the treatment of diabetes and cardiovascular diseases in China. The aim of this study was to determine the effect of AS-IV on the function and the proliferation of beta cells in diabetic mice. Methods: We used the immunostaining and
reverse transcription
polymerase chain reaction to detect the expression of insulin, Ki-67 and PDX-1 in pancreatic islets under AS-IV with or without pretreatment with statin in STZ-induced diabetic mice. The inflammation cytokine for TNF-α and MCP-1 expression were detected by ELISA in pancreases in all group mice. Results: AS-IV and statin enhanced the secreted insulin and the proliferation in beta cells and attenuated the increased expression of TNF-α an.. View More»
