Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
+44 1223 790975
ISSN: 2155-9899
+44 1223 790975
Yasuhisa Ano
Central Laboratories for Key Technologies, Kirin Company Ltd,
1-13-5 Fukuura Kanazawa-ku, Yokohama-shi, Kanagawa 236-0004
Japan
Commentary
Bitter Components in Beer Regulate Microglial Inflammation and Prevent Cognitive Decline
Author(s): Yasuhisa Ano, Akihiko Takashima and Hiroyuki NakayamaYasuhisa Ano, Akihiko Takashima and Hiroyuki Nakayama
Epidemiological studies suggest that moderate consumption of alcoholic beverages can reduce the risk of dementia . Recent work has demonstrated that intake of iso-α-acids, the bitter components in beer; prevent Alzheimer’s disease pathology by regulating microglial function. In a transgenic mouse model of Alzheimer’s disease, iso-α-acid intake led to a significant reduction of Aβ and inflammatory cytokines. In addition, iso-α-acids enhanced microglial phagocytosis of Aβ and induced microglia to an anti-inflammatory M2 type. These findings suggest that iso-α-acid consumption in daily life may be beneficial in preventing dementia.
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DOI:
10.4172/2155-9899.1000509