Yi-Xin (Jim) Wang
Crown Bioscience, Inc, Cardiovascular and Metabolic Diseases Research,
3375 Scott Blvd, STE108, 67 Bacon Court, Santa Clara, California 95054
Tanzania
Research Article
Proteinuria in Cynomolgus macaques (Macaca fascicularis) with Spontaneously Developed Metabolic Disorder and Diabetes: Transcriptome Analysis of Biopsy Kidney
Author(s): Sheng Guo, Wubin Qian, Fenglai Du, Bingdi Wang, Xiaoli Wang, Yupeng Fang, Xuan Chen, Michael Benzinou, Francine M. Gregoire, Michael Staup, Keefe Chng, Yaxiong Chen, Yong-Fu Xiao and Yi-Xin (Jim) WangSheng Guo, Wubin Qian, Fenglai Du, Bingdi Wang, Xiaoli Wang, Yupeng Fang, Xuan Chen, Michael Benzinou, Francine M. Gregoire, Michael Staup, Keefe Chng, Yaxiong Chen, Yong-Fu Xiao and Yi-Xin (Jim) Wang
Although Type 2 Diabetes Mellitus (T2DM) is well characterized Non-Human Primate (NHP), the phenotypes of diabetic nephropathy, and its molecular mechanisms are not well studied in NHPs. Diabetic nephropathy in cynomolgus macaques with spontaneous dysmetabolism (Pre-DM, n=19) and diabetes (DM, n=20) were compared with normal controls (N, n=11). There were 9 NHPs with albuminuria (>42 mg/day) in the DM (45%), only 1 in Pre-DM and none in N group. The renal function measured by estimated glomerular filtration rate (eGFR) was not significantly different among the 3 groups, indicating that these NHPs were in an early stage of renal disease. From these NHPs, 3 N, 3 Pre-DM without albuminuria and 6 DM with albuminuria were selected for transcriptome analysis of kidney biopsies. There were 95 differentially expressed genes (DEGs) detected amongst the 3 groups, of which, 75DEGs between the.. View More»
