Journal of Cancer Science and Research
Open Access

Ziyun Du

Publications

• Review Article
  Applications of CRSIPR/Cas9 in Cancer Research
  Author(s): Junming Yue, Ziyun Du, Fu-Ming Zhou, Peixin Dong and Lawrence M PfefferJunming Yue, Ziyun Du, Fu-Ming Zhou, Peixin Dong and Lawrence M Pfeffer
  
  The technology based on clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) has been successfully applied to genome editing and has shown a promising future in gene functional studies. Human cancer is a complex disease due to multiple gene mutations, amplifications, deletions, up regulations or down regulations. It is a challenge to generate precise cell or animal cancer models in vitro and in vivo to investigate the complex process of cancer. The CRISPR/Cas9 technology provides a new opportunity to study human cancer by disrupting multiple genes or introducing point mutations at a specific locus of genome, and thus mimicking the features of human cancer in cell or animal models. Here we will review the current status of CRIPSR/Cas9 system and its potential application to cancer research. .. View More»
  DOI: 10.4172/2576-1447.1000103

  Abstract PDF

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