|"Autoimmune diseases are at a greater risk of developing preeclampsia indicating these pregnancy complications may be a result of altered immune regulation. Our analysis of affected pathways identified dysregulation of intrinsic, extrinsic, and compliment activation pathways. The complement cascade involves opsonization, chemotaxis, and lysis of foreign material as part of the innate immune system and is potentiated in normotensive pregnancy. Most of the complement proteins are synthesized by the liver but they can also be produced locally by specialized cells such as macrophages and blood onocytes. Complement proteins were previously shown to be up-regulated in pree clamptic placentas but these proteins were only observed as differentially regulated in studies of serum.
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Citation: Wong F, Cox B (2014) Proteomics Analysis of Preeclampsia, a systematic Review of Maternal and Fetal Compartments. J Proteomics BioinformS10: 001."