Non-Hodgkin's lymphoma is cancer that originates in your lymphatic system, the disease-fighting network spread throughout your body. In non-Hodgkin's lymphoma, tumors develop from lymphocytes — a type of white blood cell. Non-Hodgkin's lymphoma is more common than Hodgkin lymphoma.Many different subtypes of non-Hodgkin's lymphoma exist. The most common non-Hodgkin's lymphoma subtypes include diffuse large B-cell lymphoma and follicular lymphoma. The 5-year survival rates for the different lymphoma subtypes in children (0-14 year) are slightly higher than in adolescents (Figure 32 and Figure 33). The 5-year survival rates for Hodgkin and non-Hodgkin lymphoma are 99% and 90% in children. In adolescents they are 97% and 86% respectively. Burkitt lymphoma (IIc) is rarely seen in adolescents and the number of cases are too Low for a survival analysis.
Progress in understanding DNA changes in lymphoma has already provided improved and highly sensitive tests for detecting this disease. Such tests can identify lymphoma cells based on changes such as chromosome translocations or rearrangements or specific gene mutations. Some of these tests are already in use, and others are being developed. Many effective treatment options exist for NHL patients, including:
• radiation therapy
• stem cell transplantation
• novel targeted agents