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Pediatric White Blood Cell Disorders

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  • Pediatric white blood cell disorders

    Pathophysiology

    Body produces white blood cells (leukocytes), which help fight bacterial infections, viruses and fungi. If your child has too few or too many white blood cells, in general, here's what it means: Low white blood cell count (leukopenia) means having too few leukocytes circulating in the blood. A long-term low white blood cell count increases the risk of infections and may be caused by a number of different diseases and conditions. High white blood cell count (leukocytosis) means having too many leukocytes circulating in the blood, usually from having an infection. A number of different diseases and conditions may cause a long-term high white blood cell count.

  • Pediatric white blood cell disorders

    Disease statistics

    Annually there are over 332 000 affected conceptions or births. About 275 000 have a sickle-cell disorder, and need early diagnosis and prophylaxis. About 56 000 have a major thalassaemia, including at least 30 000 who need regular transfusions to survive and 5500 who die perinatally due to α thalassaemia major.

  • Pediatric white blood cell disorders

    Treatment

    Treatments for white blood cell disorders depend on several factors, including: The type of disorder, The extent of the disorder, Your child’s overall health, Your child’s response to treatment, Your preferences Our treatments for your child’s white blood cell disorder may include: Chemotherapy, Radiation, Antibiotics, Colony-stimulating factors (these increase the body’s production of blood cells), Drugs to suppress the immune system Stem cell transplantation may be useful for some types of severe white blood cell disorders, particularly those caused by bone marrow problems

  • Pediatric white blood cell disorders

    Research

    There were 180 CVD events in men and 80 in women. The WBC count was correlated most strongly with the number of cigarettes smoked per day, hematocrit, and vital capacity. Among nonsmoking men with WBC counts within the normal range, the age-adjusted WBC count was significantly associated with CVD and coronary heart disease incidence. For each 1.0× 109/L-cell difference in WBC count, the CVD risk increased 32%. In women, each 1.0× 109/L-cell increment in WBC count was associated with a 17% increase in CVD risk, but only in smokers, and the relationship was not statistically significant after adjustment for relevant risk factors.

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