Rabies Virus can able to replicate in muscle and then binds to nicotinic acetylcholine receptors at neuromuscular junction. Virus travels within axons in peripheral nerves through retrograde fast axonal transport and Replication in motor neurons in spinal cord and local dorsal root ganglia and rapid ascent to brain. The main infected areas at brain neurons with neuronal dysfunction.
In Belgium, mostly it is like complete pre-exposure series consists of three doses of vaccine injected into the deltoid muscle on days 0, 7, and 21 or 28. The vaccines used for pre-exposure and post-exposure vaccination are the same, but the immunization pattern is different. Even when pre-exposure vaccine has been received, urgent medical advice should be sought after any animal or bat bite.
In Belgium, the statistic rate can be estimated risk for an animal bite in travelers: calculated 0.4 % (0,01 - 2,3) per month and the threat to over 3 billion of people -an estimated 55.000 human deaths every year- review of 60 cases in international travelers between 1990-2012.