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DNA anomalies in chromosomes, gene amplification, mutations in somatic cells are detected by genomic biomarkers. However these genomic analyses are not reflected at RNA and protein levels as the epigenetic changes and the post transcriptional changes ad post-translation changes affect the amount of proteins and alter the RNA. Proteins and RNA are most abundantly found in the body fluids and these are most readily affected by diseases, thus these are considered as promising biomarker.
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