|Multiple Sclerosis (MS) is a progressive inflammatory demyelinating disease of the central nervous system well known to significantly impact both bladder and bowel function. Accordingly, rates of urinary complaints in MS patients are significantly higher than in the general population, with up to 14% of patients presenting with urinary complaints as their first symptoms of disease. Increased disease duration, urinary symptoms tend to become more prevalent and severe: 39% of patients with a five year disease history report symptoms, versus 64% of patients with a disease history of 17.1 years . Urinary symptoms related to MS significantly impact quality of life for MS patients and increase economic consequences related to nursing care, supplies for management of incontinence, and resulting UTIs . Effects of MS on the bladder and their management will be discussed in this review.