The hypothalamic neuropeptide “hypocretin-1” is also named orexin-A for its influence on food intake. An intracerebroventricular injection of hypocretin-1 does not merely affects food intake, but it also causes an increase in heart rate (HR), blood pressure, and metabolic rate. These autonomic modifications indicate that this neuropeptide plays a role in the control of vegetative functions. Hypocretin-1 also affects thermoregulation, including changes in “core” temperature and temperature of interscapular brown adipose tissue (IBAT).
Messina G, Di Bernardo G, Messina A, Dalia C, Chieffi S, et al. (2014) Brief Exercise Enhances Blood Hypocretin-1 in Sedentary Men. J Sports Med Doping Stud 4: 149.