Large bone defects in the setting of large tissue loss could occur due to of many reasons such as multiple, gunshot, communited, and or other complicated fractures, bone tumors (e.g. osteosarcoma), massive avascular necrosis, severe osteomyelitis, advanced osteoporosis and open fractures. In such cases, a considerable amount of diseased bone that has no vascular supply or cannot be used in bone reconstructive surgery, should be removed from the patient’s body and the resulting defect should be stabilized and filled or reconstructed with bone substitutes.
Moshiri A, Oryan A, Shahrezaee M (2014) An Overview on Bone Tissue Engineering and Regenerative Medicine: Current Challenges, Future Directions and Strategies. J Sports Med Doping Stud 4: e144.