alexa Development of a Stability-Indicating HPLC Method for Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calcium in Bulk and Pharmaceutical Dosage Form

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Development of a Stability-Indicating HPLC Method for Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calcium in Bulk and Pharmaceutical Dosage Form

Hypertension and dyslipidemia are two most commonly cooccurring cardiovascular risk factors. Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide accounting for in excess of 930,000 deaths. It is a multifactorial disease, emphasis is to treat overall cardiovascular risk, rather than single risk factors in isolation .The third National Health and Nutrition Examination Survey (NHANES) estimated that more than 64% of patients with hypertension also have dyslipidemia; conversely, approximately 47% of patients with dyslipidemia have hypertension. Antihypertensive and lipid lowering medications substantially reduce the risk of CAD, stroke, and death in patients with cardiovascular risk factors.

 Citation: Hafez HM, Elshanawany AA, Abdelaziz LM, Mohram MS (2014) Development of a Stability-Indicating HPLC Method for Simultaneous Determination of Amlodipine Besylate and Atorvastatin Calcium in Bulk and Pharmaceutical Dosage Form. Pharm Anal Acta 5:316. doi: 10.4172/2153-2435.1000316

 

 
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