A growing interest in the use of adult stem cells for the treatment of several neurological disorders has been developed over the last few years. This is the result of a better understanding of stem cell properties as well as encouraging conclusions from studies in neurologicaldamaged animals after treatment with stem cells.
The appealing molecular and cellular properties of Mesenchymal Stem Cells (MSC), a type of adult stem cells, have prompted the concept that these cells represent a reliable candidate for cell therapy for neurological diseases. The above assertion is supported by three major facts: a) MSC can differentiate outside the mesenchymal lineage into neurological precursors, b) after infusion of MSC to animals with genetic or experimental neurological diseases, MSC migrate and survive within the central nervous system and contribute to the improvement/recovery of pre-symptomatic motor functions and c) MSC secrete several growth factors and chemokines that may create a neuroprotective environment favorable for tissue sparing and axonal regeneration.
Minguell JJ, Pereira A, Bartholomew P and Lasala GP (2011) The Intrathecal Infusion of Mesenchymal Stem Cells into Healthy Rabbits is Safe and Devoid of Neurological or Clinical Complications. J Stem Cell Res Ther 1:104. doi: 10.4172/2157-7633.1000104