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In last few years we have witnessed an explosion of research revealing the wide spread prevalence of vitamin D deficiency among all ages, communities, and different disease spectrums. Clearly, vitamin D has been shown to have effects beyond its traditional role in mineral metabolisms, which are mediated through the activation of vitamin D receptors distributed in a variety of tissues. There are strong epidemiological links between vitamin D deficiency and chronic diseases and will continue to be a focus of future research.